Hutchinson-Gilford Progeria Syndrome

Authors

  • Andrés Villamil Medical Student, Grupo de Investigación Ciencias Básicas en Salud y Grupo de Investigación Materno – Infantil. Línea Pediatría. Fundación Universitaria de Ciencias de la Salud (FUCS), Bogotá, D.C. Colombia.
  • Betty Bernal Medical Student, Grupo de Investigación Ciencias Básicas en Salud y Grupo de Investigación Materno – Infantil. Línea Pediatría. Fundación Universitaria de Ciencias de la Salud (FUCS), Bogotá, D.C. Colombia.
  • Catalina Echeverri Medical Student, Grupo de Investigación Ciencias Básicas en Salud y Grupo de Investigación Materno – Infantil. Línea Pediatría. Fundación Universitaria de Ciencias de la Salud (FUCS), Bogotá, D.C. Colombia.
  • Daniela Pulido Medical Student, Grupo de Investigación Ciencias Básicas en Salud y Grupo de Investigación Materno – Infantil. Línea Pediatría. Fundación Universitaria de Ciencias de la Salud (FUCS), Bogotá, D.C. Colombia.
  • Jhon Camacho-Cruz MD Pediatrician, Associate Instructor Department of Pediatrics, Fundación Universitaria de Ciencias de la Salud (FUCS), Bogotá, D.C. Colombia. Grupo de Investigación Materno – Infantil. Línea Pediatría.
  • Juan Pardo Medical Student, Grupo de Investigación Ciencias Básicas en Salud y Grupo de Investigación Materno – Infantil. Línea Pediatría. Fundación Universitaria de Ciencias de la Salud (FUCS), Bogotá, D.C. Colombia.
  • Laura Guarin Medical Student, Grupo de Investigación Ciencias Básicas en Salud y Grupo de Investigación Materno – Infantil. Línea Pediatría. Fundación Universitaria de Ciencias de la Salud (FUCS), Bogotá, D.C. Colombia.
  • Lizeth Angarita Medical Student, Grupo de Investigación Ciencias Básicas en Salud y Grupo de Investigación Materno – Infantil. Línea Pediatría. Fundación Universitaria de Ciencias de la Salud (FUCS), Bogotá, D.C. Colombia.
  • Luisa Bautista 3Medical Student, Grupo de Investigación Ciencias Básicas en Salud y Grupo de Investigación Materno – Infantil. Línea Pediatría. Fundación Universitaria de Ciencias de la Salud (FUCS), Bogotá, D.C. Colombia.
  • Luz Dary Gutiérrez-Castañeda MSc. in Human Genetics, Biotechnology Doctor (c), Assistant Professor, Department of Genetics, Fundación Universitaria de Ciencias de la Salud (FUCS), Bogotá, D.C. Colombia. Grupo de Investigación Ciencias Básicas en Salud.
  • Monica Bautista Medical Student, Grupo de Investigación Ciencias Básicas en Salud y Grupo de Investigación Materno – Infantil. Línea Pediatría. Fundación Universitaria de Ciencias de la Salud (FUCS), Bogotá, D.C. Colombia.
  • Natalia Lancheros Medical Student, Grupo de Investigación Ciencias Básicas en Salud y Grupo de Investigación Materno – Infantil. Línea Pediatría. Fundación Universitaria de Ciencias de la Salud (FUCS), Bogotá, D.C. Colombia.
  • Vanessa Benavides Medical Student, Grupo de Investigación Ciencias Básicas en Salud y Grupo de Investigación Materno – Infantil. Línea Pediatría. Fundación Universitaria de Ciencias de la Salud (FUCS), Bogotá, D.C. Colombia.
Abstract:

The Hutchinson-Gilford syndrome or progeria is a laminopathy generated by mutations that affect LMNA gene. This produces an abnormal protein named progerine which alters the formation of the cellular membrane inducing premature aging of all cells. In the present review aspects related to the pathophysiology and clinical characteristics of this syndrome are shown.

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Journal title

volume 7  issue 10

pages  10283- 10289

publication date 2019-10-01

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